By F.J. Dixon, Henry G. Kunkel (Eds.)
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Extra info for Advances in Immunology, Vol. 18
GENETIC DETERMINANTS OF IMMUNOLOGICAL RESPONSIVENESS 13 The discovery by McDevitt and Tyan that the Ir-1 gene of mice is closely linked to the H-2 histocompatibility locus (see Section IV,A) stimulated Benacerraf and his colleagues to search for evidence of linkage between the PLL gene and the major histocompatibility locus of guinea pigs. Among 18 backcross progeny of the generation ( 2 x 13)F, x 13, the 9 animals that were responders possessed the ( 2 x 13)F, histocompatibility type, whereas the 9 animals that were nonresponders possessed the strain 13 histocompatibility type, thus demonstrating that the PLL gene is, indeed, linked to the guinea pig's major histocompatibility locus.
C. RESPONSESTO GLA, AND GAT In studies on the antigcmicity of synthetic polypeptidc>s,Pinchuck and Mnurer ( 1965a) observed that antibocly responses could not be obtaiiicd when mice were injected with copolymcw of only two amino acids, h i t the introduction of as little as 4 mole 2 of a third amino acid resulted iii an immunogenic molecule, regardless of the nature of the third amino acid. Depending on the composition of the injected antigen, variable proportions of random-bred Swiss iiiicc, produced antibodies that were detected by passive Iie~iiagglutiiiatioi~ of antigen-coated, tanned, red blood cells.
Fraction of PHA response is given in parentheses. 16 DAVID L. GASSER AND WILLYS K. SILVERS inhibited the response to DNP-GL, whereas the same effect occurred on the GT response when strain 2 anti-13 sera were used. To rule out the possibility that inhibition was caused by blocking cell surface immunoglobulins, the alloantisera were absorbed with y-globulin of the opposite strain. No decrease in the inhibitory activity of either of the alloantisera was observed after these absorptions. It was concluded that Ir genes produce a cell surface-associated product and that this product plays a role in the mechanism of antigen recognition by the T lymphocytes.